Proton pump inhibitors (PPIs)—medications commonly used to treat heartburn, acid reflux, and ulcers—have been linked with potentially serious side effects including a possible increased risk of bone fractures. In a new Alimentary Pharmacology & Therapeutics study, however, patients with Barrett’s eosophagus—a long-term complication of acid reflux— who took high doses of PPIs for prolonged periods were no more likely to have bone fractures or evidence of bone thinning (osteopenia or osteoporosis) than people in the general population.
Statins used for the treatment of high cholesterol may have other beneficial effects, but there has been reluctance to prescribe them to patients with liver disease because of concerns that they may cause abnormal liver enzyme levels in the blood. In a new Alimentary Pharmacology & Therapeutics analysis of data from the Danish National Patient Registry, patients with cirrhosis of the liver due to alcohol had a 43% lower risk of dying prematurely than patients not on statins.
The intestinal barrier of patients with the gastrointestinal disease IBS allows bacteria to pass more freely than in healthy people, according to a study led by researchers at Linköping University in Sweden. The study, published in the scientific journal Gastroenterology, is the first to investigate IBS using living bacteria.
Infections during infancy are associated with increased risk for gluten intolerance (celiac disease) later on. Apparently the risk is particularly high in the case of repeated gastrointestinal infections in the first year of life. This conclusion was drawn by scientists of the Institute for Diabetes Research at Helmholtz Zentrum München, a partner in the German Center for Diabetes Research (DZD), after analyzing data provided by the Bavarian Association of Statutory Health Insurance Physicians. Results from this study have now been published in the current issue of the ‘American Journal of Epidemiology’.
Novel study finds evidence for association between breastfeeding duration and maternal obesity and development of nonalcoholic fatty liver disease in adolescents, reports the Journal of Hepatology