This website is intended for Medical Professionals only. By using this site you confirm that you are a healthcare professional.

News
Be extra vigilant about heart attack ... Health systems should warn high risk patients by smartphone when ... (17 May 2018)
CrossFit improves how people with type 2 ... New research published in Experimental Physiology has suggested ... (17 May 2018)
Keep saying yes to fish twice a week for ... A new scientific advisory reaffirms the American Heart ... (17 May 2018)
Imaging Breast Implant Rupture Dr Pierre Vassallo - Breast augmentation is the most common form ... (18 May 2018)
The 39th World Medical & Health Games ... Sports Director Pierre Chicco talks Medigames with TheSynapse. ... (18 May 2018)
Friday, 14 July 2017 13:02

Low doses of radiation could harm cardiovascular health, study suggests Featured

Rate this item
(0 votes)

Ionizing radiation, such as x-rays, has a harmful effect on the cardiovascular system even at doses equivalent to recurrent CT imaging, a new study published in the International Journal of Radiation Biology suggests.


cardiacCTIt is known that populations exposed to ionizing radiation in medical or environmental settings have symptoms suggesting an increased risk of cardiovascular disease. However, this research study suggests that low exposure to doses of around 0.5 Gy (the equivalent of repeated CT scans) is associated with a significantly increased risk of cardiovascular damage, up to decades after exposure. This raises questions about the nature of long-term alterations in the heart’s vascular system caused by such doses.
Dr Soile Tapio and Dr Omid Azimzadeh of Helmholtz Zentrum München, German Research Center for Environmental Health, and colleagues studied how human coronary artery endothelial cells respond to a relatively low radiation dose of 0.5 Gy and found several permanent alterations in the cells that had the potential to adversely affect their essential functions.
Endothelial cells, which form the inner layer of blood vessels, were found to produce reduced amounts of nitric oxide, an essential molecule in several physiological processes including vascular contraction. Previously, high-dose radiation (16 Gy) has been shown to persistently reduce levels of nitric oxide in the serum of mice, but this is the first study to indicate impaired nitric oxide signaling at much lower doses.
Cells damaged by low-dose radiation also produced increased amounts of reactive oxygen species (ROS), which are formed as a natural byproduct of normal oxygen metabolism and play an important role in cell signaling. Increased ROS can damage DNA and proteins.
In addition, exposed cardiac endothelial cells were found to have reduced capacity to degrade oxidised proteins and to be aging prematurely. Such harmful changes did not occur immediately (that is, within a day) but first began in the longer term (one to two weeks). As these cells do not divide rapidly in the body, this observed time in the cell culture would correspond to several years in the living organism.
All these molecular changes are indicative of long-term premature dysfunction and suggest a mechanistic explanation to the epidemiological data showing increased risk of cardiovascular disease after low-dose radiation exposure, the authors conclude.

 

 



Source: Taylor & Francis

Full bibliographic information:
International Journal of Radiation Biology; Proteome analysis of irradiated endothelial cells reveals persistent alteration in protein degradation and the RhoGDI and NO signalling pathways; Omid Azimzadeh, Vikram Subramanian, Susanne St€ander, Juliane Merl-Pham, Donna Lowe, Zarko Barjaktarovic, Simone Moertl, Ken Raj, Michael J.

Read 1515 times Last modified on Monday, 17 July 2017 20:46

Media

TheSynapse Videos

0
0
0
0
0
0

Latest news

Highlights

  • WASP Course in Bahrain

    WASP Course, led by Prof Victor Grech and Prof Charles Savona Ventura, has recently organised a course in Bahrain. Co-hosted with Arabian Gulf University, the course, on how to write a scientific paper, focused on quantitative analysis methods and was targeted for medical doctors and allied health professionals.

    Written on April 24, 2018 Read more...

SPONSOR MESSAGE

Join

Connect with other Medical Professionals on fb in a closed facebook group

Login

Template Settings

Theme Colors

Cyan Red Green Oranges Teal

Layout

Wide Boxed Framed Rounded
Patterns for Layour: Boxed, Framed, Rounded
Top
We use cookies to improve our website. By continuing to use this website, you are giving consent to cookies being used. More details…