This website is intended for Medical Professionals only. By using this site you confirm that you are a healthcare professional.

News
Interactive Discussion on Valsartan     The Malta Medicines Authority in collaboration with the ... (21 Jul 2018)
Caffeine affects food intake at breakfast, ... Findings of a new study published in the Journal of the Academy ... (17 Jul 2018)
New approach to treating infectious diseases ... Osaka University scientists clarify how E.coli bacteria attach ... (17 Jul 2018)
The more you smoke, the greater your risk of ... The more you smoke, the greater your risk of atrial ... (17 Jul 2018)
New Cochrane health evidence challenges ... New evidence shows there is little or no effect of omega 3 ... (17 Jul 2018)
Friday, 16 March 2018 19:58

Long-term proton pump inhibitor use does not increase hip fracture risk among Alzheimer’s patients Featured

Rate this item
(0 votes)

Long-term proton pump inhibitor (PPI) use does not increase the risk of hip fracture among persons with Alzheimer’s disease, according to a new study from the University of Eastern Finland. The risk of hip fracture was slightly increased for PPI use of less than one year, but not for long-term or cumulative use during a follow-up period of 10 years. In addition, there were no significant differences between PPI drug substances and the associated risk of hip fracture. The findings were published in Alimentary Pharmacology & Therapeutics.

Some previous studies have suggested that long-term PPI use may increase the risk of hip fracture. According to this new study, however, the risk of hip fracture is not increased even in long-term use. Proton pump inhibitors are effective drugs for dyspepsia, gastroesophageal reflux disease and peptic ulcer and they are commonly and increasingly used among older population.. Due to their gastro-protective properties, they are also co-prescribed with nonsteroidal anti-inflammatory drugs and corticosteroids.

The study is based on the register-based MEDALZ-cohort comprising data on all community-dwelling persons diagnosed with Alzheimer’s disease in Finland in 2005–2011. The study population included 4,818 persons with Alzheimer’s disease and an incident hip fracture, and 19,235 persons without hip fracture. The mean age of the study population was 84 years. For each person with Alzheimer’s disease who experienced their first hip fracture, up to four controls without hip fracture were matched by age, sex and time since the Alzheimer’s disease diagnosis. All proton pump inhibitors available in Finland were investigated.

The analyses were adjusted for other medication increasing the risk of fall, osteoporosis, socioeconomic status, long-term hospital care, history of psychiatric diseases, and chronic diseases increasing the risk of fall or fracture.



Source: University of Eastern Finland (UEF Viestintä)
Full bibliographic information:
Proton pump inhibitor use and risk of hip fractures among community-dwelling persons with Alzheimer’s disease – A nested case-control study.
Alimentary Pharmacology & Therapeutics, 2018,

Read 467 times Last modified on Friday, 16 March 2018 21:18

TheSynapse Videos

0
0
0
0
0
0

Latest news

Highlights

  • Interactive Discussion on Valsartan

     

     

    The Malta Medicines Authority in collaboration with the Superintendence
    of Public Health and the Department of Pharmacy University of Malta
    would like to cordially invite you to an interactive scientific discussion:

     

     


    THE VALSARTAN SAGA


    SCIENCE | MYTHS | REALITIES

     


    led by Professor Anthony Serracino Inglott

     


    Date: Wednesday 25 July 2018

     


    Time: 20:00
    Venue: Conference Room, Life Sciences Park, San Ġwann

     


    Refreshments will be served


    RSVP: info.medicinesauthority@gov.mt | 23439202

    Written on July 21, 2018
  • WASP Course in Bahrain

    WASP Course, led by Prof Victor Grech and Prof Charles Savona Ventura, has recently organised a course in Bahrain. Co-hosted with Arabian Gulf University, the course, on how to write a scientific paper, focused on quantitative analysis methods and was targeted for medical doctors and allied health professionals.

    Written on April 24, 2018 Read more...

Join

Connect with other Medical Professionals on fb in a closed facebook group

captcha  

Login

Template Settings

Theme Colors

Cyan Red Green Oranges Teal

Layout

Wide Boxed Framed Rounded
Patterns for Layour: Boxed, Framed, Rounded
Top
We use cookies to improve our website. By continuing to use this website, you are giving consent to cookies being used. More details…