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Thursday, 25 August 2016 00:00

Imaging Small Bowel Disease

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Pierre Vassallo

The small intestine is the most difficult part of the gastrointestinal tract to evaluate due to its length, complex loops and its distance from the mouth and anus. Conventional endoscopic techniques such as push enteroscopy (reaches up to 120cm beyond the ligament of Treitz) and colonoscopy with ileoscopy do not reach most of the small bowel. A complete direct endoscopic evaluation was previously possible only with intraoperative endoscopy.

Non-invasive small bowel evaluation is possible with indirect methods such as barium examination, computed tomography (CT), and magnetic resonance (MR) imaging. Suboptimal bowel distension and overlapping bowel loops make radiologic evaluation challenging.

Capsule endoscopy, introduced in 2000, is a new diagnostic tool that makes use of a swallowable video capsule, which, unlike conventional endoscopy, allows visualisation of the entire small bowel and does not require sedation.

The endoscopy capsule measures 26 x 11 mm and weighs 4 g (Fig 1). It contains a video camera, light source, radio transmitter, and batteries. Eight sensors attached to the patient’s abdomen receive the images, which are stored on a portable hard disk recorder strapped around the patient’s waist.

The capsule acquires two colour images per second with a resolution of 256 x 256 pixels. The sensors also allow a rough approximation of the capsule location inferred from the time of intestinal transit. After 8 hours, the data stored on the recorder is viewed on a computer workstation. The single-use capsule is excreted naturally, usually within 8–72 hours, but sometimes after as along as 2 weeks.

The main indication for capsule endoscopy is unexplained intestinal bleeding or blood loss of indeterminate aetiology. Detection of early Crohn’s disease may be challenging with radiologic techniques, and more easily achieved with capsule endoscopy. Additional potential indications for capsule endoscopy may include evaluation of patients with hereditary polyposis syndromes, small bowel damage induced by nonsteroidal anti-inflammatory drugs (NSAIDs), chronic diarrhea, or chronic abdominal pain.

The main disadvantage of capsule endoscopy is the inability to definitively localize or treat small bowel lesions. A rough approximation of capsule location is based on time, however this is prone to inaccuracy due to differences in small bowel transit time or variant anatomy. Capsule endoscopy cannot be used in cases of intestinal strictures or obstruction; this includes more advanced cases of Crohn’s disease due to intestinal strictures.

An initial radiographic study such as a small bowel barium enema, barium follow-through or CT with bowel contrast is recommended for suspected small bowel disease; if negative, and patency of intestinal tract has been confirmed, capsule endoscopy may be performed. The following paragraphs describe the most common small intestinal diseases, in which this investigative approach has been shown to be of value.

Arteriovenous malformations, also referred to as angiodysplastic lesions, telangiectasias, or angioectasias, are the most common abnormality accounting for obscure gastrointestinal bleeding. They occur more frequently with increasing age and are seen at endoscopy as spider-like lesions (Fig 2). They are visible on angiography and CT angiography during a bleeding episode. These lesions can be treated with cauterization or hormone therapy.

Small bowel tumours (Figs 3-5)are a less common, accounting for only 1.4% of gastrointestinal cancers. Nonetheless these lesions are an important cause of obscure gastrointestinal bleeding and account for 75% of the symptomatic small bowel lesions that require surgery.

Small bowel ulcers (Figs 6-7) are another common abnormality detected at capsule endoscopy. Although the majority of small bowel ulcers detected at capsule endoscopy are due to Crohn’s disease or NSAIDs, other causes include infection, ischemia, trauma, or vasculitis.

Figure Legends

Figure 1: The endoscopy capsule measures 26x11mm.

 Fig 2a  Fig 2b Fig 2c 

Figure 2: Bleeding angioectasia in a patient with obscure gastrointestinal bleeding. (a) Capsule endoscopic image shows angioectasia (encircled). (b) Angiogram shows angioectasia (arrows) in the jejunum. (c) Intraoperative endoscopic image helps confirm bleeding angioectasia in the jejunum (arrow).

Fig 3

Figure 3: Gastrointestinal stromal tumour. Coronal CT scan shows a gastrointestinal stromal tumour (encircled), a finding that was confirmed surgically. Capsule endoscopy was non-diagnostic due to retained food.

 Fig 4a Fig 4b 

Figure 4: Familial polyposis in a patient with negative findings at small bowel follow-through examination and CT. Capsule endoscopic (a) and push endoscopy (b) images show multiple small polyps in the proximal small bowel (arrows).

 Fig 5a Fig 5b   Fig 5c Fig 5d 

Figure 5: Lymphangioma. (a) Capsule endoscopic image shows multiple punctate white lesions (encircled) in the proximal small bowel. (b) Intraoperative endoscopic image shows markedly thickened small bowel folds. (c) CT scan shows circumferential low-attenuation wall thickening in a jejunal segment (encircled) causing narrowing of the lumen and enlargement of the small bowel loop. (d) Intraoperative photograph shows marked distension of a jejunal loop, a finding that corresponds to the abnormality seen at CT.

Fig 6

Figure 6: Small bowel ulcers. Capsule endoscopic image shows small bowel ulcers that were not seen at enteroclysis or CT.

 Fig 7a  Fig 7b Fig 7c 

Figure 7: Early Crohn’s disease. (a) Image from a small bowel follow-through study shows mild nodularity in the terminal ileum (arrows). (b) CT scan shows mild diffuse wall thickening and mucosal enhancement of the terminal ileum (arrow). (c) Capsule endoscopic image shows a small apthous ulcer in the terminal ileum (circled).

Additional Info

  • TheSynapse Magazines: 2006
Read 3643 times Last modified on Sunday, 20 November 2016 15:11

Dr Pierre Vassallo MD PhD FACA Artz fur Radiologie specialised in radiology at the Institute of Clinical Radiology at the University of Muenster, Germany and the Memorial Sloan-Kettering Cancer Center, New York, US. He is currently Consultant Radiologist and Managing Director at DaVinci Health, Malta.

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