Non-invasive brain stimulation, combined with cognitive training, could significantly improve symptoms of attention deficit hyperactivity disorder (ADHD) in children, according to new research jointly led by the University of Surrey and the Hebrew University of Jerusalem.


In a clinical trial involving 23 unmedicated children (6 to 12 years old) with ADHD, researchers set out to find out whether a novel form of brain stimulation that involves a mild electrical current on the brain through two electrodes, during cognitive training, can improve the symptoms of ADHD.

After a two-week programme of brain stimulation, the study found that 55% of children showed significant clinical improvements in ADHD symptoms, as reported by their parents. This was compared to 17 percent in the control group who received sham (placebo) brain stimulation, during cognitive training.

The study also found that these improvements were maintained three weeks after the end of the treatment, with 64 percent reporting clinically meaningful responses to the treatments. This is compared to 33 percent in the control group.

Professor Roi Cohen Kadosh, co-lead of the study, Head of the School of Psychology and Professor of Cognitive Neuroscience at the University of Surrey, said:

“I believe that the scientific community is duty-bound to investigate and develop evermore effective and longer-lasting treatments for ADHD. The findings we demonstrate in our study suggest that a combination of transcranial direct current stimulation (tRNS), which is shown to be safe with minimal side effects, has the potential to transform the lives of children and their families.

“The results from this proof-of-concept study, together with previous results we received using tRNS, increase our confidence that in the future non-invasive brain stimulation may be able to provide an alternative to medication as a treatment pathway for children. However, our important test will be the results from a multi-centre clinical trial with a larger sample that we will start soon. If successful, this approach will be approved as a medical device for ADHD by the United States Food and Drug Administration.”

ADHD is a brain condition that affects people’s attention, activity, and impulsivity. Around 5.2 percent of children worldwide have the condition, which usually manifests itself with children struggling with focus, memory, and self-control.

Following the treatment, the research team also noticed changes in the children’s brain electrical activity patterns that continued even at the 3-week follow-up.

Dr Mor Nahum, co-lead of the study and Head of the Computerized Neurotherapy Lab at the Hebrew University where the study took place adds that “This is an important first step in offering new therapeutic options for ADHD. Future studies, with larger and more varied samples, should help establish this as a viable therapy for ADHD, and help us understand the underlying mechanisms of the disorder.”

Professor Itai Berger, co-lead of the study, Head of Pediatric Neurology previously at Hadassah, currently at Assuta-Ashdod University Medical Center who recruited the study participants add that: “If the results will be replicated in future larger studies we will be able to offer a novel, promising non-invasive, and safe treatment to large number of children and their families not only in the field of ADHD but in other neuro-developmental disorders.”

Ornella Dakwar-Kawar, a post-doctoral researcher at The Hebrew University of Jerusalem

“ADHD is one of the most common neurodevelopmental disorders affecting children across the world. Treating the condition with medication improves a child’s attention span and overall mood, however in certain cases there can be side effects including headache and a loss of appetite. There is therefore a pressing need for developing and testing novel, non-pharmacological interventions for ADHD. Results from the current proof-of-concept study provide a preliminary direction towards a novel intervention in pediatric ADHD.”

The study has been published by Translational Psychiatry. This research was funded by a grant from the Israel Innovation Authority to Tech Innosphere Engineering Ltd.

Full bibliographic information
Published on 31/07/2023 by University of Surrey
Paper title: Transcranial Random Noise Stimulation Combined with Cognitive Training for Treating ADHD: A Randomized, Sham-Controlled Clinical Trial
DOI: 10.1038/s41398-023-02547-7
Authors: Professor Roi Cohen-Kadosh
Journal: Translational Psychiatry